Levosimendan Intermediate CAS 36725-28-7 Purity >99.5% (HPLC) Factory

Short Description:

Chemical Name: 6-(4-Aminophenyl)-4,5-Dihydro-5-Methyl-3(2H)-Pyridazinone

CAS: 36725-28-7

Purity: >99.5% (HPLC)

Appearance: Off-White to Pale Brownish Color Powder

Intermediate of Levosimendan (CAS: 141505-33-1)

High Quality, Commercial Production

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Product Detail

Product Tags

Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of 6-(4-Aminophenyl)-4,5-Dihydro-5-Methyl-3(2H)-Pyridazinone (CAS: 36725-28-7) with high quality, commercial production. We can provide COA, worldwide delivery, small and bulk quantities available. Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name	6-(4-Aminophenyl)-4,5-Dihydro-5-Methyl-3(2H)-Pyridazinone
Synonyms	6-(p-Aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone; 1,4-Dihydro-4-Methyl-3-(4-Aminophenyl)pyridazine-6(5H)-one ; Levosimendan Impurity 5
CAS Number	36725-28-7
CAT Number	RF-PI1976
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C11H13N3O
Molecular Weight	203.25
Melting Point	194.0 to 198.0℃
Density	1.30±0.10 g/cm3
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Appearance	Off-White to Pale Brownish Color Powder
Identification (HPLC)	HPLC RT of the major peak corresponds to that of the in-house working standard
Loss on Drying	<0.50%
Residue on Ignition	<0.20%
Related Substances	(HPLC)
Single Impurity	<0.20%
Total Impurities	<0.50%
Purity / Analysis Method	>99.5% (HPLC)
Heavy Metals	<20ppm
Proton NMR Spectrum	Conforms to Structure
Test Standard	Enterprise Standard
Usage	Intermediate of Levosimendan (CAS: 141505-33-1)

Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture

Advantages:

FAQ:

Application:

6-(4-Aminophenyl)-4,5-Dihydro-5-Methyl-3(2H)-Pyridazinone (CAS: 36725-28-7) is an intermediate of Levosimendan (CAS: 141505-33-1). Levosimendan was introduced in Sweden as an i.v. infusion for the treatment of acute heart failure or refractory symptoms of chronic heart failure in cases where conventional treatment (e.g., diuretic or ACE inhibitor) is not sufficient. It also activates ventricular and arterial adenostne triphosphate-regulated potassium channels which causes vasodilatation in vascular smooth muscle and protects myocardium against infarction. Its low phosphodiesterase III inhibiting activity is probably not responsible for its positive inotropic, lusitropic and dilating effects. Unlike other cardiotonic drugs, levosimendan is able to produce positive inotropic effects without prolonging myocardial relaxation or increasing the incidence of malignant arrythmias. It was clinically shown to have a lower risk of mortality in patients with heart failure when compared to placebo and dobutamine. Since it has a larger potential, levosimendan is currently under further clinical evaluation as a chronic treatment for congestive heart failure.